TOXINDIA-Services

Ecotoxicology Studies

Comprehensive OECD-compliant studies assessing the impact on aquatic and terrestrial organisms, pollinators, and soil health.

OECD 201 Aquatic Test: Freshwater Algae, Cyanobacteria & Growth Inhibition Test
OECD 202/211 Daphnia Immobilization & Reproduction Test
OECD 203 Acute Fish (Guppy/Zebrafish) Toxicity Study
OECD 207/222 Acute Earthworm Toxicity & Reproduction Study
OECD 208 Terrestrial Plant Test: Seedling Emergence & Growth Test
OECD 213/214 Acute Oral & Contact Honey Bees Toxicity Study
OECD 223 Acute Avian Toxicity Study (Quail, Pigeon, Chicken)
OECD 216/217 Soil Microorganism: Nitrogen & Carbon Transformation Tests
OECD 220/235 Studies on Worms (Enchytraeids / Chironomus spp.)
Other Insects & Arachnids: Silkworms, Carabid Beetles, Aphids, Lycosid Spiders, Predatory Mites

Acute Toxicity Studies

Establish safety profile of new compounds through acute and irritation/corrosion tests.

OECD 423/425 Acute Oral Toxicity Studies – Rat and Mouse
OECD 402 Acute Dermal Toxicity – Rat and Rabbit
OECD 403 Acute Inhalation Toxicity – Rat
OECD 404 Acute Dermal Irritation/Corrosion – Rabbit
OECD 405 Acute Eye Irritation/Corrosion – Rabbit
OECD 406 Skin Sensitization (GPMT/Buehler) – Guinea Pig

Repeated Dose Toxicity Studies

Systemic toxicity evaluations for subacute to chronic exposures across species.

OECD 407, 410, 412 28-Day Repeated Dose Oral/Dermal/Inhalation Toxicity Study – Rat and Mouse, with or without recovery and TK assessment
OECD 408 90-Day Repeated Dose Toxicity Study – Rat and Mouse, with or without recovery and TK assessment
OECD 414 Prenatal Developmental Toxicity Study
OECD 416 Two-Generation Reproduction Toxicity Study
OECD 443 Extended One-Generation Reproductive Toxicity Study
OECD 452 Chronic Toxicity – Rat and Mouse
OECD 453 Combined Chronic Toxicity/Carcinogenicity Study – Rat
OECD 451 Carcinogenicity Study – Rat and Mouse

Genetic Toxicology

We conduct a comprehensive suite of genetic toxicology studies to evaluate potential mutagenic and clastogenic effects using internationally recognized guidelines.

OECD 471 Bacterial Reverse Mutation Test (AMES test)
OECD 473 In vitro Chromosome Aberration Test in CHO Cell Lines
OECD 474 In vivo Micronucleus Test in Mouse
OECD 475 In vivo Chromosome Aberration Test in Mouse
OECD 476 In Vitro Mammalian Cell Gene Mutation Test using the HPRT and xprt Genes
OECD 487 In vitro Micronucleus Test in CHO Cell Lines

Safety Pharmacology

We evaluate the potential effects of compounds on vital physiological systems, helping identify adverse pharmacological effects before clinical use

Cardiovascular Safety Studies

Comprehensive assessment of cardiovascular function and hemodynamics

Respiratory Safety Studies

Evaluation of respiratory function and potential adverse effects

Neurological Safety Studies

Assessment of effects on the central and peripheral nervous systems

Central Nervous System Safety

Evaluation of motor activity, sedation, and neurological effects

Renal Safety

Assessment of urine output and markers of kidney function

Gastrointestinal Safety

Evaluation of motility, tolerance, and adverse GI effects

Toxicokinetics & IND-Enabling Studies

Our toxicokinetics (TK) and IND-enabling services provide systemic exposure and ADME data that support regulatory decision-making and product development.

TK Study Design

Customized study designs to evaluate systemic exposure

Bioanalysis

Validated analytical methods for quantification of test compounds

Pharmacokinetic Analysis

Comprehensive PK parameter calculation and interpretation

IND-Enabling Packages

Integrated study packages for IND applications

Chemistry

Our Chemistry services are conducted in full compliance with global guidelines including ASTM, EEC, FDA, ICH, OECD, OPPTS, SANCO, ABNT NBR, WHO, and others. These studies support the quality, stability, and regulatory requirements of active ingredients and formulations.

Analytical Chemistry Services

Method Development and Validation
5-Batch Analysis
Physical and Chemical Properties of Active Ingredients
Physical and Chemical Properties of Formulation and Technical Product

Stability Studies

Storage Stability
Accelerated Storage Studies
Long-term Storage Stability & Corrosion Studies (1–5 Years)
Stability at Shelf Life (1-Year / 2-Year / 5-Year / Cold Temperature)
Storage Stability with Metal and Metal Ions at Normal and Elevated Temperature

Environmental Fate Studies

Hydrolysis
Residues in Soil
Residues in Water
Soil Microorganisms

Transformation Tests

Nitrogen Transformation Test
Carbon Transformation Test

Biocompatibility & Medical Device Testing

In accordance with ISO 10993 standards, we offer in vitro and in vivo assessments for medical devices and biomaterials.

In vitro cytotoxicity

Assessment of cell death and growth inhibition

Sensitization

Evaluation of potential allergic responses

Irritation or Intracutaneous Reactivity

Assessment of local tissue responses

Pyrogenicity Testing – Rabbits

Evaluation of fever-inducing potential

Genotoxicity

Assessment of DNA damage and mutagenic potential

Systemic Toxicity

Evaluation of whole-body adverse effects

Hemocompatibility

Assessment of blood-material interactions

Reproductive Toxicity

Evaluation of effects on reproduction and development

Services

Comprehensive Preclinical Testing Services