Physical-Chemical Testing Laboratory
The studies are offered in full compliance with global guidelines, viz. ASTM, EEC, FDA, ICH, OECD, OPPTS, SANCO, ABNT NBR, WHO, and others.
Capabilities Include:
- Method development and Validation
- 5-Batch Analysis
- Physical and chemical properties of active ingredients
- Physical and chemical properties of formulation and Technical product
- Storage Stability
- Accelerated storage studies
- Long-term Storage Stability & Corrosion Characteristics Studies (1 – 5 Years)
- Stability at Shelf life (storage stability) – One year / 2-year / 5-year / Cold temperature
- Storage Stability – With metal and metal ions at normal and elevated temperature
- Hydrolysis
- Residue & Persistence Studies
- Residues in Soil
- Residues in Water
- Soil Microorganisms
- Nitrogen Transformation Test
- Carbon Transformation Test
Toxicology Facilities
Our toxicology unit is designed for mammalian safety testing across a wide range of endpoints, ensuring regulatory compliance and scientific integrity.
Mammalian Toxicity Studies
- Oral Toxicity (acute & repeated dose)
- Dermal Toxicity (acute & repeated dose)
- Inhalation Toxicity (acute & repeated dose)
- Skin Irritation/Corrosion (in vivo, OECD 404)
- Eye Irritation/Serious Eye Damage (in vivo, OECD 405)
- Skin Sensitization (in vivo, OECD 406)
Repeated Dose Toxicology – 14-day, 28-day, 90-day, and chronic toxicity studies in rodents, with toxicokinetics and recovery arms, aligned with OECD and ICH guidelines.
Environmental Toxicology
Dedicated infrastructure for assessing the impact of chemicals on aquatic and terrestrial organisms, ensuring ecological safety.
Capabilities include:
- Acute Fish Toxicity (OECD 203)
- Acute Earthworm Toxicity (OECD 207)
- Acute Oral Toxicity in Birds (OECD 223)
- Acute Oral and Contact Toxicity in Honeybees (OECD 213 & 214)
Genetic Toxicology / Mutagenicity
We offer a comprehensive panel of in vitro and in vivo genetic toxicology studies, aligned with OECD guidelines:
- Chromosomal Aberration Test (in vitro) – OECD 473
- Bacterial Reverse Mutation (Ames Test) – OECD 471
- Chromosomal Aberration Test (in vivo) – OECD 475
- Micronucleus Test (in vitro) – OECD 487
- Micronucleus Test (in vivo) – OECD 474
Animal House Facility
TOXINDIA's GLP-compliant vivarium is designed for animal welfare, biosafety, and controlled study environments.
Key features:
- HEPA-filtered Air Handling Units (AHUs) to ensure pathogen-free airflow.
- Controlled Light-Dark Cycles for regulated circadian rhythm.
- Quarantine Rooms for new animal arrivals.
- Clean & Reverse Corridor Systems to prevent cross-contamination.
- Dedicated Autoclave Facilities for sterilization of cages and instruments.
- Managed by trained veterinarians and skilled animal care staff with expertise in OECD-guideline animal studies.
Rodents / Small Animals
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Mouse
Rat
Rabbit
Guinea Pig
Fish
Zebrafish
Guppy Fish
Birds
Chicken
Pigeon
Quail
Other Test Systems
Earthworm
Honeybee
Daphnia
Lemna
Histopathology
Our histopathology facility provides microscopic evaluation of tissues, critical for toxicological interpretation.
Capabilities:
- Tissue Fixation (formalin and other fixatives)
- Tissue Processing Assembly (embedding, dehydration, clearing, and paraffin infiltration)
- Microtomy – Precision thin-sectioning of tissues using rotary microtomes
- Special Staining Protocols (H&E and advanced histochemical stains)
- Digital Microscopy for high-resolution imaging and reporting
Clinical Chemistry
Our clinical pathology unit supports toxicology studies with biochemical and hematological evaluations for systemic effects of test items.
Capabilities include:
- Serum Biochemistry (enzymes, electrolytes, metabolites)
- Hematology (RBC, WBC, platelet counts, hemoglobin)
- Urinalysis (pH, protein, glucose, microscopic sediment analysis)
- Specialized biomarker assessments as per study requirements.
